9c4239e3-c6be-405a-b42e-bae90430982820220118041835496naun:naunmdt@crossref.orgMDT DepositInternational Journal of Biology and Biomedical Engineering1998-451010.46300/91011http://www.naun.org/cms.action?id=3041110202211020221610.46300/91011.2022.16https://npublications.com/journals/bio/2022.phpKisangKwonDepartment of Clinical Laboratory Science, Wonkwang Health Science University, Iksan 54538, KoreaYounghwaKoDepartment of Anatomy & Cell Biology, College of Medicine, Chungnam National University, Daejeon 35015, KoreaHyewonParkDepartment of Anatomy & Cell Biology, College of Medicine, Chungnam National University, Daejeon 35015, KoreaJunghaeKimDepartment of Anatomy & Cell Biology, College of Medicine, Chungnam National University, Daejeon 35015, KoreaKyung-HeeKangDepartment of Dental Hygiene, College of Medical Science, Konyang University, Daejeon 35365, KoreaSeung-WhanKimDepartment of Emergency Medicine, College of Medicine, Chungnam National University, Daejeon 35015, KoreaO-YuKwonDepartment of Anatomy & Cell Biology, College of Medicine, Chungnam National University, Daejeon 35015, KoreaAlthough glibenclamide is an oral hypoglycemic agent used in type 2 diabetes, skeletal muscle wasting has been reported as a side effect. To understand how to reduce this side effect, we determined whether glibenclamide induces endoplasmic reticulum (ER) stress in skeletal muscle cells and which myokine expression changes at this time. The ER chaperone genes do not show a significant change by glibenclamide, but the ER stress sensor genes are upexpressed approximately twice, and those downstream [ATF6 (activating transcription factor 6) fragmentation, eIF2α (eukaryotic initiation factor-2α) phosphorylation, and XBP1 (Xbox DNA-binding protein) mRNA splicing] are activated. Additionally, the myokine gene expression was up- or downregulated by glibenclamide. These results will serve as useful data for overcoming the side effects of sarcopenia caused by glibenclamide.1182022118202216116721https://npublications.com/journals/bio/2022/a422010-021(2022).pdf10.46300/91011.2022.16.21https://npublications.com/journals/bio/2022/a422010-021(2022).pdf10.5114/aoms.2015.53304D. Sola, L. Rossi, G. P. Carnevale Schianca, P. Maffioli, M. 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